Sceletium tortuosum as an antidepressant

There are few studies of effects of Sceletium tortuosum in human subjects. In an interesting fMRI study, acute administration of 25 mg of Zembrin, a proprietary preparation of Sceletium tortuosum, attenuated reactivity to fearful faces in the amygdala. Follow-up connectivity analysis on the emotion-matching task further showed that amygdala-hypothalamus coupling was also reduced. Those results were interpreted as reflecting an anxiolytic dampening of activity in threat circuitry of the human brain