Proesence Articles

Biological and Pharmaceutical Properties of Sceletium tortuosum

This article appeared on the US National Library of Medicine and National Institutes of Health website. Abstract Sceletium tortuosum (L.) N.E.Br. (Mesembryanthemaceae), commonly known as kanna or kougoed, is an effective indigenous medicinal plant in South Africa, specifically to the native San and Khoikhoi tribes. Today, the plant has gained strong global attraction and reputation due to its capabilities to promote a sense of well-being by relieving stress with calming effects. Historically, the plant was used by native San hunter-gatherers and Khoi people to quench their thirst, fight fatigue and for healing, social, and spiritual purposes. Various studies have revealed that extracts of the plant have numerous biological properties and isolated alkaloids of Sceletium tortuosum are currently being used as dietary supplements for medicinal purposes and food. Furthermore, current research has focused on the commercialization of the plant because of its treatment in clinical anxiety and depression, psychological and psychiatric disorders, improving mood, promoting relaxation and happiness. In addition, several studies have focused on the isolation and characterization of various beneficial bioactive compounds including alkaloids from the Sceletium tortuosum plant. Sceletium was reviewed more than a decade ago and new evidence has been published since 2008, substantiating [...]

Biological and Pharmaceutical Properties of Sceletium tortuosum2021-09-15T03:59:57-04:00

Kanna: What is it and How Can it Improve Your Life?

Written by Cort Honey KannaCalm is a brand new supplement based around an alkaloid extract of the Sceletium tortuosum, or Kanna, plant. The plant contains three main psychoactive alkaloids; Mesembrine, Mesembrenone, and delta Mesembrenone. While these alkaloids are psychoactive, they are NOT hallucinogenic. Each of these three alkaloids produce different effects, so different concentrations of these alkaloids in a supplement help relieve different symptoms. Additionally, the dose and method of consumption also cause the effects of Kanna to vary greatly. Kannacalm is designed around producing a calming effect to help relieve anxiety, stress, and tension. To produce these effects, the extract in KannaCalm contains 50% Mesembrine with the other 50% being made up of Mesembrenone and delta Mesembrenone. KannaConnect on the other hand helps promote connectedness and focus with about 70% Mesembrine and 30% Mesembrenone and delta Mesembrenone. What is Kanna? Kanna is a succulent plant belonging to the Sceletium genus that naturally grows in South Africa. It grows through spreading outward on the ground, oftentimes with exposed roots. The leaves are typically green with red tips and it produces flowers with white petals that turn to yellow in the middle of the flower similar in appearance [...]

Kanna: What is it and How Can it Improve Your Life?2020-11-23T03:53:51-05:00

Sceletium tortuosum (Kanna)

Kanna (Sceletium tortuosum) is a plant that’s been used in South Africa for hundreds of years. It contains substances (e.g. Mesembrine and Mesembrenone) which offer depressant and anxiolytic effects. The drug also seems to enhance the effects of cannabis, particularly its euphoria.

Sceletium tortuosum (Kanna)2020-07-06T11:01:52-04:00

Kanna Plant Review: Benefits, Uses, Dosages and Where to Buy

Also known as, “Sceletium Tortuosum“ in botany, Kanna is one of the most commonly used traditional herbs that work wonders for mind-alteration. Its impact on the evolution of human consciousness is profound. Since it is naturally available, consumers conveniently enjoy its mood boosting and anxiety-reducing effects.

Kanna Plant Review: Benefits, Uses, Dosages and Where to Buy2020-07-02T16:29:24-04:00

Sceletium Tortuosum (Kanna) Overview: History, Benefits, Effects & More

Conveniently enough, some of the most notorious stress relief ingredients are derived from all-natural herbs and other plants which are known to have minimal (if any) side effects. One of the most underrated of these herbs is known as Sceletium tortuosum, or simply Kanna. Let’s take a look at what this ingredient can bring to the table for those coping with stress.

Sceletium Tortuosum (Kanna) Overview: History, Benefits, Effects & More2020-06-29T17:04:27-04:00

Sceletium tortuosum as an antidepressant

There are few studies of effects of Sceletium tortuosum in human subjects. In an interesting fMRI study, acute administration of 25 mg of Zembrin, a proprietary preparation of Sceletium tortuosum, attenuated reactivity to fearful faces in the amygdala. Follow-up connectivity analysis on the emotion-matching task further showed that amygdala-hypothalamus coupling was also reduced. Those results were interpreted as reflecting an anxiolytic dampening of activity in threat circuitry of the human brain

Sceletium tortuosum as an antidepressant2020-06-25T11:13:09-04:00

What is Kanna (Sceletium Tortuosum)

El mundo que nos rodea está tan agitado como el infierno. Este caos viene en muchas formas; social, profesional, lo que consumes, la lista es interminable! Afortunadamente, hay un montón de grandes mentes buscando formas de lidiar con este estrés. Una de las cosas con las que nos hemos tropezado y que está empezando a tener más prevalencia es algo llamado Kanna.

What is Kanna (Sceletium Tortuosum)2020-06-19T16:50:28-04:00

Kanna (Sceletium tortuosum) as a Treatment for Stress and Depression

Kanna (Sceletium tortuosum) is a succulent plant native to South Africa. Kanna is also often referred to as channa. A medicine made from kanna called Zembrin is also available. Kanna is used in traditional medicine as a treatment for both stress and depression, which suggests that it contains phytochemicals that affect the central nervous system. A fermented form of kanna called kougoed is also produced and used medicinally for this reason.

Kanna (Sceletium tortuosum) as a Treatment for Stress and Depression2020-06-18T13:16:58-04:00

Sceletium Tortuosum

Scelectium tortuosum has been traditionally used to manage anxiety and depression, as well as to enhance mood, cognitive activity, and memory. However, clinical trials supporting these uses are lacking.

Sceletium Tortuosum2020-06-16T13:25:16-04:00

Mental Health Benefits of Sceletium

Like other chronic and seemingly intractable illnesses, the incidence of depression is reaching epidemic levels. In fact, according to the World Health Organization, depression is the leading cause of disability worldwide, and an estimated 350 million people of all ages suffer from depression. It’s a complex and notoriously difficult to treat condition. It often occurs alongside comorbidities such as anxiety, chronic pain and obesity, but it may also present as an isolated issue with no obvious underlying cause(s). The reduced quality of life caused by depression is difficult for patients to soldier through, and healthcare professionals may feel frustrated that they have limited options to offer patients beyond pharmaceutical drugs that frequently induce side-effects that may be nearly as unpleasant as the depression, itself. Patients and medical professionals alike are seeking natural remedies that are safe and effective for combating depression. Commonly employed compounds include St. John’s wort, 5-HTP, and vitamins B6, B12, and folate. A lesser-known but efficacious compound for boosting mood as well as addressing some of the other issues that may occur along with depression—anxiety, in particular—is sceletium, also known as Kanna, Channa, or Kougoed. This extract is considered a nootropic, and comes [...]

Mental Health Benefits of Sceletium2019-05-19T07:08:48-04:00
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